Prevention of breast cancer skeletal metastases with parathyroid hormone
نویسندگان
چکیده
منابع مشابه
Prevention of breast cancer skeletal metastases with parathyroid hormone.
Advanced breast cancer is frequently associated with skeletal metastases and accelerated bone loss. Recombinant parathyroid hormone [teriparatide, PTH(1-34)] is the first anabolic agent approved in the US for treatment of osteoporosis. While signaling through the PTH receptor in the osteoblast lineage regulates bone marrow hematopoietic niches, the effects of anabolic PTH on the skeletal metast...
متن کاملProstate cancer, serum parathyroid hormone, and the progression of skeletal metastases.
Bony metastases from prostate cancer are a significant cause of morbidity and mortality. These metastases are predominantly blastic (bone-forming) and commonly cause increased serum levels of parathyroid hormone (PTH) as calcium ions are transferred from serum into blastic bone. The epidemiologic and clinical significance of secondary hyperparathyroidism in advanced prostate cancer have not bee...
متن کاملZosteriform Skin Metastases from Breast Cancer
Metastatic skin cancer is a rare complication of internal malignancies. Patients who develop cutaneous metastases rarely present with a zosteriform distribution. Herein, we describe a 65-year-old woman with a prior history of breast cancer in whom zosteriform metastases developed along her left T8-9 abdominal dermatomes.
متن کاملParathyroid hormone related protein and hypercalcaemia in breast cancer.
OBJECTIVE To see whether parathyroid hormone related protein has a humoral role in breast cancer. DESIGN Plasma concentrations and tumour expression of parathyroid hormone related protein were determined (by two site immunoradiometric assay and immunohistochemistry respectively) in women with breast cancer and related to the presence of bone metastases and serum calcium concentrations. SUBJ...
متن کاملPolymerase chain reaction analysis of parathyroid hormone-related protein gene expression in breast cancer patients and occurrence of bone metastases.
Parathyroid hormone-related protein (PTHrP) is associated with the syndrome of humoral hypercalcemia of malignancy. A high incidence of positive staining for PTHrP is observed in breast cancer and positivity is more frequent in patients who develop bone metastases. We assessed the presence of PTHrP mRNA by using the polymerase chain reaction in 38 normocalcemic breast cancer patients with long-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JCI Insight
سال: 2017
ISSN: 2379-3708
DOI: 10.1172/jci.insight.90874